gout-care-gout-help-gout-attacks-gout-health-gout-pain-doctors
Alternative Health Research LLC

Gout Care By Smith & Smith Est.1998


   




Order 24 hours a day 7 days a week online or by phone!
Call 1-877-633-4688

cart
Customer Reviews








FDA

gout-help-gout-products-gout-care-good-manufacturing-practice

What is GMP Click Here?
Kevin Eric Smith ,
+1-877-633-4688
U.S.A
doctor-group


Gout Care Newsletter

Welcome to Health-Gout-News by

Smith & Smith Enterprises




Be sure to like us on Facebook

https://www.facebook.com/goutexperts/
Our goal is to bring you the latest in important information regarding the health of you and your loved ones. We thank you for joining us each month and hope that you take the time to enjoy these news updates, our delicious recipes, and take advantage of great savings each and every month. Please be sure to contact us should you have any questions at all! Contact, coupons, and site information can be found below. Thank You!


Be sure to like us on Facebook
and "friend" us, too!  

New model of Alzheimer's as an autoimmune disease

Date:
September 27, 2022
Source:
University Health Network
Summary:
Scientists have proposed a new mechanistic model (AD2) for Alzheimer's, looking at it not as a brain disease, but as a chronic autoimmune condition that attacks the brain.

Scientists at the Krembil Brain Institute, part of the University Health Network, have proposed a new mechanistic model (AD2) for Alzheimer's, looking at it not as a brain disease, but as a chronic autoimmune condition that attacks the brain.

This novel research is published today, in Alzheimer's & Dementia.

"We don't think of Alzheimer's as fundamentally a disease of the brain. We think of it as a disease of the immune system within the brain," says Dr. Donald Weaver, co-Director of the Krembil Brain Institute and author of the paper.

Alzheimer's disease, the most common form of dementia, impacts more than 50 million people around the world, with a new person being diagnosed every three seconds. Yet, despite more than 200 clinical trials in the past 30 years, there are no disease modifying therapeutics to prevent, halt or treat Alzheimer's.

"We need new ways of thinking about this disease, and we need them now," says Dr. Weaver. "To date, most of the approaches in Alzheimer's research have been based upon the theory that a protein called beta-amyloid, which is supposedly abnormal in the brain, clumps up. And when it clumps up, it kills brain cells."

"But we believe beta-amyloid is right where it should be. It acts as an immunopeptide -- a messenger within our immune system -- so that, if we have head trauma, beta-amyloid repairs it. If a virus or a bacteria comes along, beta-amyloid is there to fight it."

That's where the problem occurs, says Dr. Weaver. "Beta-amyloid gets confused and can't tell the difference between a bacteria and a brain cell and so it inadvertently attacks our own brain cells. This, then, becomes what we call an autoimmune disease. The immune system is actually attacking the host, our brain."

Noted in the team's findings:

• The research team conducted a comprehensive search, looking at a wide-ranging review of both journal and patient literatures combined with their own studies, to develop a thorough mechanistic model of Alzheimer's.

• The AD2 model endeavours to harmonize other mechanistic propositions (including proteopathy, synaptotoxicity and mitochondriopathy), while recognizing beta-amyloid as a physiologically oligomerizing immunopeptide and part of a much larger and broad, highly-interconnected immunopathic process.

• Within the AD2 model, amino acid metabolism of L-tryptophan and L-arginine emerge as innate immunity regulators, thus pointing to new diagnostic and therapeutic approaches.

Tangible rethinking about Alzheimer's disease as an autoimmune disease, and beta-amyloid as a normal part of our immune system, opens the door to new avenues and approaches to develop innovative new therapies, says Dr. Weaver.

"We are very excited in our lab. We think that this autoimmune theory is sound and represents a significant conceptual step forward."

This work was funded through operating grants from the Canadian Institutes of Health Research, the Weston Foundation, the Krembil Foundation and a Harrington Scholar-Innovator Award from the Harrington Discovery Institute.

Dr. Weaver acknowledges salary support from a Canada Research Chair, Tier 1, in protein misfolding.


Story Source:

Materials provided by University Health NetworkNote: Content may be edited for style and length.


Journal Reference:

  1. Donald F. Weaver. Alzheimer's disease as an innate autoimmune disease (AD 2 ): A new molecular paradigmAlzheimer's & Dementia, 2022; DOI: 10.1002/alz.12789

 Black Bean Breakfast Bowl

Ingredients

  • 2 tablespoons olive oil (real butter or ghee alt)

  • 4 eggs, beaten

  • 1 (15 ounce) can black beans, drained and rinsed

  • 1 avocado, peeled and sliced

  • 1/4 cup salsa

  • Himalayan salt and ground black pepper to taste

  • Directions

  1. Heat olive oil in a small pan over medium heat. Cook and stir eggs until eggs are set, 3 to 5 minutes.

    Place black beans in a microwave-safe bowl. Heat on High in the microwave until warm, about 1 minute.
  2. Divide warmed black beans between two bowls.
  3. Top each bowl with scrambled eggs, avocado, and salsa. Season with salt and black pepper.

        **Please remember that our recipes are intended for use WITH our products and program, both of which allow for more flexibility in your diet and lifestyle accompanied by the right balance.**


    Savings of the Month


     

    Save 5% off all orders - No minimum required

    Coupon Code: save5

     

    Save 10% off all orders of $100.00 or more

    Coupon Code: save10 

     

    Save 15% off all orders of $180.00 or more

    Coupon Code: save15

    Coupons work on both sites

    www.goutcure.com

    www.ahr4health.net

    Try our new 3 month package deal!

    Click to enlarge

  • 2 Bottles of GC® GoutCare for Joint Health & Uric Acid Control
  •  

  • 1 Bottle of Flamasil® for Cellular, Joint, & Total Health
  •  

  • 2 New Body Boost® Mega Vitamins with Green Superfoods
  •  

  • 1 Bottle of Friendly Fighter Pro® (90 count) 2 Billion Probiotic Cells
  • Joint and Cellular Health Package 2/GC 2/BB 1/Flam 1/FF90
    1661-Flam

    www.goutcure.com  

    www.ahr4health.net 

    DISCOUNTS EXPIRE December 3rd, 2023


    Contact Us

     

    Alternative Health Research LLC

    T/A Smith and Smith Enterprises,

    11941 Main St. #130 

    Libertytown, MD 21762

    Phone: 1-877-633-4688

    Email: customerservice@goutcare.com

    Fax: 1-877-686-6762







    Order online 100% securely ~ All your information will be encrypted with 128 bit encryption (high) RSA with 1024 bit exchange.
    *The products have not been evaluated by the Food and Drug Administration, and they are not intended to diagnose, treat, or cure any disease.


    We accept Mastercard, Visa, PayPal, and American Express. Copyright 1998-2023 Goutcure.com / Goutcare.com / OrderGC.com / Stopgout.com / Gout-Care.com / AHR4Health.com.
    Alternative Health Research LLC T/A Smith and Smith Enterprises 11941 Main St. - Unit 130, Libertytown, MD 21762-1100 . All Rights Reserved.

    Privacy Policy



    All Products Page
    Yahoo and Shopper Approved Testimonials
    Privacy Policy
    Question and Answers About Gout Care
    Order Forms
    24 Hour Order Desk
    World Wide Distributors
    Join Our NewsLetter
    Company and Shipping Information







    *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.