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Key Points About
Prednisone (Detalsone):

Prednisone is a Glucocorticoid
steroid prescribed for a wide-range
of conditions, including Gout.

Prednisone is used as an
anti-inflammatory and/or an
immunosuppressant medication

Steroids can weaken your
immune system and make it easier
for you to get an infection

Patients with liver or kidney
disease, heart disease, diabetes, or
other serious health conditions
should consider other
Gout treatment options

Steroids can cause serious
side effects that should be
discussed with your doctor

Is Prednisone (Deltasone) a Safe and Effective Gout Treatment?

PREDNISONE, commonly known as Deltasone, is increasingly prescribed for gout management. While it can be necessary in some cases, this immunosuppressive drug is associated with significant long-term side effects. These include cataracts, bone loss leading to osteoporosis, weakened immune system function, and various others.

Commonly reported side effects of prednisone include increased stomach acid, sodium retention, delayed wound healing, reduced infection-fighting ability, bone and muscle issues, acne, night sweats, elevated blood sugar levels, and thrush (a yeast infection in the mouth, often indicative of a compromised immune system).

Some of the dangers of prednisone include:

1. Osteoporosis: Long-term use of prednisone can lead to bone loss, increasing the risk of osteoporosis and fractures.

2. Suppressed immune system: Prednisone suppresses the immune system, making individuals more susceptible to infections and delaying wound healing.

3. Cataracts and glaucoma: Prolonged use of prednisone can increase the risk of developing cataracts (clouding of the eye's lens) and glaucoma (increased pressure within the eye).

4. Weight gain: Prednisone can cause fluid retention and increased appetite, leading to weight gain, particularly in the face ("moon face") and abdomen.

5. High blood sugar: Prednisone can elevate blood sugar levels, increasing the risk of diabetes or worsening control in individuals with existing diabetes.

6. Psychological effects: Some individuals may experience mood swings, irritability, anxiety, or depression while taking prednisone.

7. Gastrointestinal issues: Prednisone can irritate the lining of the stomach, leading to ulcers or gastrointestinal bleeding, especially when taken without food or in high doses.

8. Adrenal insufficiency: Prolonged use of prednisone can suppress the body's natural production of cortisol, leading to adrenal insufficiency when the medication is discontinued suddenly.

9. Muscle weakness: Prednisone can cause muscle weakness and loss, particularly with long-term use.

10. Skin problems: Some individuals may experience thinning of the skin, easy bruising, or delayed wound healing while taking prednisone.

Corticosteroid medications like prednisone can effectively control inflammation and pain associated with gout. They may be administered orally or via joint injections. Typically, corticosteroids are prescribed for individuals who cannot tolerate NSAIDs or colchicine. Dietary supplements and programs like ours may offer support in mitigating the side effects associated with prednisone use and promoting overall health and healing.

It's essential for individuals taking prednisone to be closely monitored by their healthcare provider and to discuss any concerns or potential side effects. Prednisone should be used at the lowest effective dose for the shortest duration possible to minimize risks.

Reduced Cortisol Levels (by Livestrong.com)

Prednisone has the general effect of suppressing the function of the adrenal glands, thereby reducing the levels of hormones secreted by the adrenal glands. Cortisol, a hormone that plays an important role in the body's response to stress, is greatly suppressed even after taking low doses of prednisone, according to a study published in the 2006 issue of "Alternative Medicine Review." Low levels of cortisol have been known to cause many symptoms, including chronic fatigue and weakness, weight loss, stomach upset, vomiting, headache and low blood pressure leading to dizziness and fainting, reports the National Endocrine and Metabolic Diseases Information Service.

Several other hormones regulated by the adrenal glands are also suppressed by prednisone, including cortisone, dehydroepiandrosterone, androsterone, aldosterone and tetrahydrocorticosterone, reports Alternative Medicine Review. The suppression of these hormones has several different effects. For example, dehydroepiandrosterone, abbreviated DHEA, is involved in regulating hormones involved in reproduction, brain function and the immune response. Suppression of DHEA may reduce the levels of sex hormones, weaken the bones, reduce the immune response and affect moods and mental functioning. People taking prednisone may sometimes also be prescribed DHEA to counteract these effects.

Adrenal Crisis

A person who is taking prednisone should never suddenly stop taking the medication. Because prednisone is a hormone that alters the body's delicate balance of hormones, suddenly removing prednisone from the equation can cause a temporary case of secondary adrenal insuffciency, which is sometime called an adrenal crisis, explains MedlinePlus. An adrenal crisis can cause many of the same symptoms as low cortisol levels, including fatigue, abdominal or side pain, nausea and vomiting, fever, low blood pressure and loss of appetite. Doctors usually gradually reduce the dosage of prednisone before completely stopping the medication to reduce these effects.

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